منابع مشابه
ZIP codes for delivering SH2 domains
Around the year 1990, it was discovered that src-homol-ogy 2 (SH2) domains could bind to phosphotyrosine A number of proteins implicated in protein-tyrosine kinase signaling pathways were known to contain SH2 domains, and this discovery revealed how these proteins could form multimeric signaling complexes in response to activation of growth factor receptor family protein-Tyr kinases. However, t...
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PRIMARY LUNG DISEASE, the associated inflammatory response, and treatment with supplemental oxygen all result in the generation of increased amounts of reactive oxygen species (ROS), which can cause significant damage to the lung. The susceptibility of the lung to oxidative injury depends largely on the ability to upregulate protective ROS scavenging systems. Unfortunately, both intracellular a...
متن کاملWhen zip codes are in short supply.
b-Actin mRNA requires the RNA-binding protein ZBP1 for trafficking to distal regions of the cytoplasm. In this issue of The EMBO Journal, Donnelly et al show that ZBP1 is a limiting and essential factor for adult axonal regeneration in vivo, via trafficking of additional mRNAs. These findings highlight a complex web of interactions between RNA-binding proteins and cargo mRNAs. Intracellular tra...
متن کاملStructure and function of SH2 domains.
In order for cells to respond to their environment, a series of regulated molecular events has to take place. External signalling molecules bind to cellular receptors and thereby trigger the activation of multiple intracellular pathways, which modify cellular phenotypes. The cell-surface receptors for a wide range of polypeptide hormones possess protein tyrosine kinase activity, which is induce...
متن کاملSH2 domains: A question of independence
The three-dimensional structures of parts of two enzymes that contain tandem Src homology 2 (SH2) domains have recently been determined. The structures suggest how the SH2 domains function in concert to regulate enzymatic activity and localization.
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ژورنال
عنوان ژورنال: Cell
سال: 2004
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(04)00041-8